My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Also feed bland diet- rice, ground beef, chicken, cottage cheese. Stressing out now. Vets have told us repeatedly that it can't be the medication. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. It seems to be clearing up with Rx eye drops. best of luck to all whose furry ones have gotten sick from this and as well hugs to those who lost their beloved pets. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Took to vet and she said it could be the Simparico Trio. This sure seems like this happening way too often . Now, here we are one month later and I just gave him the second dose about two hours ago. However, they are possible, so it is better to know they might happen. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. Today is Friday. I to also gave my best friend Simparica as recommended by the vet. Product Details: Simparica Trio Chewables for dogs. Hoping for a good outcome!!! Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. I am interested in the petition and the company's response. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. She started it on 7/22. Normal. I put water with electrolytes by his cage & food . Benefits: Each tablet provides a full month of protection against fleas and ticks. Today shes been panting. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. Any other alternatives that are not harmful? oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. Very "out of it". I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. Im certain that its the simparica. My other two dogs had a little loose stool but nothing else. I hate pills for me so I struggle giving this to him. (147 Reviews) $18.38 - $44.91. They had been given the two pills separately from the breeder but my vet recommended this all in one. Two months no flare up no more scabs and loosing hair. My sincere sympathies to those with horrendous seizure side effects. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. I am so worried after reading these comments. FREE shipping and the BEST customer service! Advised her to put a big note on our account that she is never to have this again. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. The only change I could think of he started taking Simparica about 4 months ago. I will never give my dog this medication again. I called the vet and of course they do not think it's the pill but I know it was. Vet trip and meds $400! What are the side effects of simparica trio for dogs? Shame on you! He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Today, he wouldn't eat or drink any water. She's pacing and wants to eat grass. Hes very lethargic and constant vomiting! He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. I am so mad at myself for letting the vet talk me into this. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. Im going to keep a close watch on him over the next few days. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. I just found these comments and I am feeling terrible. No appetite, not like Charlie. My 9 month old puppy started acting very lethargic after taking simparica trio. Coincidence? corgi lying in grass next to woman's feet. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. I have a happy healthy 14 yr old female bull terrier. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. Thank you for giving information on what happened to your dog. I will be discontinuing the medication. Sorry to hear about this happening to so many. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. Call the FDA. I would NEVER recommend this medication. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. Those with Diarrhea symptom, did it look like mucus in their pets stool? I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. and now i'm on an hour by hour let's see if she will perk up. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. I am convinced this medicine is HORRIBLE and is causing this. Then they come back! Even when asked to go for a car ride he didn't respond. The Simparica was recommended by the vet. But im 99% sure the simparica is what caused it. Use with caution in dogs with a history of seizures or neurologic disorders. He first started with seizures and losing weight in June after giving him Simparica. I'll be spreading the word. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. They still will not consider that it is the Simparica Trio. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. And he was on Comfortis before and did fine. We received the first dose of this medication from our Vet! I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! My lab puppies have been taking Simparica Trio for 2 months. Lethargic and confused. The door is open , its where he prefers to sleep on a doggie bed . I regret putting her on this drug. Ive read these stories and am also disgusted. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. She falls when she runs and when going up and down stairs. My poor baby! I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. MONEY!!. And it looks like the liver and/or the kidney will not take it too. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). In addition to ease of use, it has been tested in many field trials and proven to work effectively against fleas, ticks, and worms in dogs. No seizures yet thank goodness, but he is drinking a ton of water. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. He protected our livestock from coyotes for many years and I took good care of him. UPDATE We had one normal day on Friday. Just our own personal experience but I won't get burned again! Did you do this yourself or let the vet? He could not hold down any food or water. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. Has odd agitated swallowing when not eating anything. Vet gave her a shot which stopped it. The day after administering drug he had two incapacitating seizures. I wanted to investigate a bit before dosing him. All the swelling went down immediately and the itching went away too. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. Im praying over him too . I have ordered what I normally use and will throw this in the trash! I called the vet and they said it was likely brought on by stress. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . It all depends, sadly. The .gov means its official.Federal government websites often end in .gov or .mil. I do believe it caused her blindness. That sh-t should be banned. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. She said to watch for drainage. All they care about is the money and not the animal. I hope I have found the culprit to his digression. Any suggestion? His first was a week after taking his simparica. I only stumbled on the side effects of this drug via a post on a Spinone group. This is whats happening to our pup, can you please tell me how long it lasted? As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. We have a 3 month old Aussie labradoodle and the breeder warned against oral flea meds. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. I am so sorry for your loss. I want to cry I wish I could get it out of her system after reading these comments. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Just gave my baby her first dose. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. If she continues I will be going to the vet. 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